The LMNA gene does not cause the disease on its own. The gene provides the code with which the protein Lamin A and the protein Lamin C can be created. The defect in the genetic code causes protein Lamin A to be structured incorrectly, and as a result the protein does not function as it should. This incorrectly structured Progeria protein is called ‘Progerin’.
Step 2: Subsequently Lamin A must still remove 15 amino acids, that is still attached, resembling a little tail of fat. When this tail of fat is ‘cut off’, it is possible for Lamin A to form the strong lamina layer on the cell nucleus membrane.
The resulting structurally incomplete lamina layer is called progerin.
And as a result, the mutated Lamin A, or progerin, can cause Progeria.